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복잡계 자기조립 연구단
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Application of Neuron-Selective Fluorescent Probe, NeuA, To Identify Mouse Retinal Degeneration

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Title
Application of Neuron-Selective Fluorescent Probe, NeuA, To Identify Mouse Retinal Degeneration
Author(s)
Park, Sung-Jin; Woon, Queenie Tan Shu; Er, Jun Cheng; Wong, Bernice H.; CSC; Kang, Nam-Young; Barathi, Veluchamy A.; Silver, David L.; Young-Tae Chang
Publication Date
2021-06
Journal
ChemBioChem, v.22, no.11, pp.1915 - 1919
Publisher
John Wiley and Sons Inc
Abstract
© 2021 Wiley-VCH GmbHThe retina is part of the central nerve system (CNS) and has various interneurons and sensory neurons such as photoreceptor cells. Retinitis pigmentosa (RP) is an inherited condition that is characterized by photoreceptor degeneration. Herein, we developed a fluorescent probe-NeuA-for detecting retinal neuronal cells and applied NeuA to discriminate between healthy and RP retinas. The staining pattern of NeuA in the retinas of healthy and RP mouse models was examined in vitro, ex vivo and in vivo using confocal microscopy, the fluorescent fundus microscopy and optical coherent tomography (OCT). NeuA strongly stained the outer segment layer of photoreceptor cells and some bipolar cells in the healthy retina, but there was only weak staining in the photoreceptor degenerated retinas. Therefore, NeuA probe can be used as the detecting RP tools in the preclinical conditions.
URI
https://pr.ibs.re.kr/handle/8788114/9737
DOI
10.1002/cbic.202100011
ISSN
1439-4227
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
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