Magnetic Resonance Imaging Diagnosis of Metastatic Lymph Nodes in a Rabbit Model: Efficacy of PJY10, a New Ultrasmall Superparamagnetic Iron Oxide Agent, with Monodisperse Iron Oxide Core and Multiple-Interaction Ligands
Cited 2 time in
Cited 0 time in
- Magnetic Resonance Imaging Diagnosis of Metastatic Lymph Nodes in a Rabbit Model: Efficacy of PJY10, a New Ultrasmall Superparamagnetic Iron Oxide Agent, with Monodisperse Iron Oxide Core and Multiple-Interaction Ligands
- Yoo, RE; Seung Hong Choi; Cho, HR; Jeon, BS; Kwon, E; Kim, EG; Park, J; Myeong, WJ; Won, JK; Lee, YS; Kim, JH; Park, SW; Sohn, CH
- PLOS ONE, v.9, no.9, pp.e107583 -
- PUBLIC LIBRARY SCIENCE
- Background: Accurate diagnosis of lymph node metastasis is crucial in treatment planning for cancer patients. Despite the
use of various parameters, making correct diagnosis of a small metastatic or a hyperplastic benign node is still a challenge.
In this study, we evaluated the feasibility of detecting lymph node metastasis using a new ultrasmall superparamagnetic
iron oxide particle, PJY10, in a rabbit model.
Methods: To make metastatic and benign lymph nodes, either VX2 carcinoma or fecal material suspension was inoculated
into thighs of 56 rabbits three weeks or three days before magnetic resonance (MR) imaging, respectively. T2*-weighted 3T
MR imaging was performed before and 24 hours after PJY10 injection (5.2 [n = 15], 7.8 [n = 17], and 10.4 [n = 24] mg Fe/kg).
MR images were correlated with pathologic results to calculate sensitivity and specificity. Quantitative analysis of the signal
intensity (SI) . number of voxels[low] (the fraction of the number of voxels with the normalized SI on the postcontrast image
lower than that on the precontrast image) and mean SI ratio . was also performed for each lymph node.
Results: Sensitivities were 100% at all three dosages, whereas specificity increased with increasing dosage (89% at 10.4 mg
Fe/kg). The benign nodes had a significantly higher number of voxels[low] and a lower mean SI ratio than the metastatic
nodes at the dosage of 10.4 mg Fe/kg (P,.001). Az values were 0.905 for the number of voxels[low] and 0.952 for the mean
SI ratio. The number of voxels[low] (P = .019) and the mean SI ratio (P = .034) had significant correlations with the
histopathologic area ratio of metastatic foci in the metastatic nodes at 10.4 mg Fe/kg.
Conclusions: PJY10 enabled clear demonstration of lymph node metastasis with high sensitivity and specificity at its
optimal dosage of 10.4 mg Fe/kg.
Appears in Collections:
- Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
- Files in This Item:
- Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.