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Advances in drug delivery technology for the treatment of glioblastoma multiforme

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Title
Advances in drug delivery technology for the treatment of glioblastoma multiforme
Author(s)
Cha, Gi Doo; Kang, Taegyu; Baik, Seungmin; Kim, Dokyoon; Choi, Seung Hong; Hyeon, Taeghwan; Kim, Dae-Hyeong
Subject
CONVECTION-ENHANCED DELIVERY, ; MALIGNANT GLIOMA, ; MAGNETIC NANOPARTICLES, ; 5-AMINOLEVULINIC ACID, ; FOCUSED ULTRASOUND, ; PROGNOSTIC-FACTORS, ; BRAIN-TUMORS, ; GENE-THERAPY, ; ANGIOGENESIS-INHIBITOR, ; ADJUVANT TEMOZOLOMIDE
Publication Date
2020-12-10
Journal
JOURNAL OF CONTROLLED RELEASE, v.328, pp.350 - 367
Publisher
ELSEVIER
Abstract
Glioblastoma multiforme (GBM) is a particularly aggressive and malignant type of brain tumor, notorious for its high recurrence rate and low survival rate. The treatment of GBM is challenging mainly because several issues associated with the GBM microenvironment have not yet been resolved. These obstacles originate from a variety of factors such as genetics, anatomy, and cytology, all of which collectively hinder the treatment of GBM. Recent advances in materials and device engineering have presented new perspectives with regard to unconventional drug administration methods for GBM treatment. Such novel drug delivery approaches, based on the clear understanding of the intrinsic properties of GBM, have shown promise in overcoming some of the obstacles. In this review, we first recapitulate the first-line therapy and clinical challenges in the current treatment of GBM. Afterwards, we introduce the latest technological advances in drug delivery strategies to improve the efficiency for GBM treatment, mainly focusing on materials and devices. We describe such efforts by classifying them into two categories, systemic and local drug delivery. Finally, we discuss unmet challenges and prospects for the clinical translation of these drug delivery technologies.
URI
https://pr.ibs.re.kr/handle/8788114/8993
DOI
10.1016/j.jconrel.2020.09.002
ISSN
0168-3659
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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