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A sensitive and specific nanosensor for monitoring extracellular potassium levels in the brain

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Title
A sensitive and specific nanosensor for monitoring extracellular potassium levels in the brain
Author(s)
Jianan Liu; Li, FY; Wang, Y; Pan, LM; Lin, PH; Zhang, B; Zheng, YR; Xu, YW; Liao, HW; Giho Ko; Fei, F; Xu, CL; Du, Y; Kwangsoo Shin; Dokyoon Kim; Jang, SS; Chung, HJ; Tian, H; Wang, Q; Guo, W; Nam, JM; Chen, Z; Taeghwan Hyeon; Ling, DS
Publication Date
2020-04
Journal
Nature Nanotechnology, v.15, pp.321 - 330
Publisher
Nature Publishing Group
Abstract
Extracellular potassium levels in the brain can be correlated to neural activity. A selective potassium sensor, in which cations other than potassium are shielded by a membrane, can measure potassium concentration changes in the brain of freely moving mice undergoing epileptic seizures. Extracellular potassium concentration affects the membrane potential of neurons, and, thus, neuronal activity. Indeed, alterations of potassium levels can be related to neurological disorders, such as epilepsy and Alzheimer's disease, and, therefore, selectively detecting extracellular potassium would allow the monitoring of disease. However, currently available optical reporters are not capable of detecting small changes in potassium, in particular, in freely moving animals. Furthermore, they are susceptible to interference from sodium ions. Here, we report a highly sensitive and specific potassium nanosensor that can monitor potassium changes in the brain of freely moving mice undergoing epileptic seizures. An optical potassium indicator is embedded in mesoporous silica nanoparticles, which are shielded by an ultrathin layer of a potassium-permeable membrane, which prevents diffusion of other cations and allows the specific capturing of potassium ions. The shielded nanosensor enables the spatial mapping of potassium ion release in the hippocampus of freely moving mice
URI
https://pr.ibs.re.kr/handle/8788114/8930
DOI
10.1038/s41565-020-0634-4
ISSN
1748-3387
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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