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Facilitated Transdermal Drug Delivery Using Nanocarriers-Embedded Electroconductive Hydrogel Coupled with Reverse Electrodialysis-Driven Iontophoresis

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Title
Facilitated Transdermal Drug Delivery Using Nanocarriers-Embedded Electroconductive Hydrogel Coupled with Reverse Electrodialysis-Driven Iontophoresis
Author(s)
An, YH; Lee, J; Son, DU; Kang, DH; Park, MJ; Kyoung Won Cho; Kim, S; Kim, SH; Ko, J; Jang, MH; Lee, JY; Dae-Hyeong Kim; Hwang, NS
Subject
iontophoresis, ; electroconductive hydrogel, ; reverse electrodialysis, ; nanocarriers, ; transdermal drug delivery system
Publication Date
2020-04
Journal
ACS NANO, v.14, no.4, pp.4523 - 4535
Publisher
AMER CHEMICAL SOC
Abstract
© 2020 American Chemical Society. We herein developed an iontophoretic transdermal drug delivery system for the effective delivery of electrically mobile drug nanocarriers (DNs). Our system consists of a portable and disposable reverse electrodialysis (RED) battery that generates electric power for iontophoresis through the ionic exchange. In addition, in order to provide a drug reservoir to the RED-driven iontophoretic system, an electroconductive hydrogel composed of polypyrrole-incorporated poly(vinyl alcohol) (PYP) was used. The PYP hydrogel facilitated electron transfer from the RED battery and accelerated the mobility of electrically mobile DNs released from the PYP hydrogel. In this study, we showed that fluconazole- or rosiglitazone-loaded DNs could be functionalized with charge-inducing agents, and DNs with charge modification resulted in facilitated transdermal transport via repulsive RED-driven iontophoresis. In addition, topical application and RED-driven iontophoresis of rosiglitazone-loaded DNs resulted in an effective antiobese condition displaying decreased bodyweight, reduced glucose level, and increased conversion of white adipose tissues to brown adipose tissues in vivo. Consequently, we highlight that this transdermal drug delivery platform would be extensively utilized for delivering diverse therapeutic agents in a noninvasive way
URI
https://pr.ibs.re.kr/handle/8788114/8665
DOI
10.1021/acsnano.0c00007
ISSN
1936-0851
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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