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Nanovesicles derived from iron oxide nanoparticles-incorporated mesenchymal stem cells for cardiac repair

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Title
Nanovesicles derived from iron oxide nanoparticles-incorporated mesenchymal stem cells for cardiac repair
Author(s)
Lee J.-R.; Park B.-W.; Jonghoon Kim; Choo Y.W.; Kim H.Y.; Yoon J.-K.; Kim H.; Hwang J.-W.; Kang M.; Kwon S.P.; Song S.Y.; Ko I.O.; Park J.-A.; Ban K.; Taeghwan Hyeon; Park H.-J.; Kim B.-S.
Subject
MYOCARDIAL-INFARCTION, ; ISCHEMIC-HEART, ; C-JUN, ; EXOSOMES, ; HYPOXIA, ; IMPROVE, ; ANGIOGENESIS, ; ACTIVATION, ; MICRORNAS, ; INJECTION
Publication Date
2020-04
Journal
SCIENCE ADVANCES, v.6, no.18, pp.eaaz0952
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Abstract
© 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. Because of poor engraftment and safety concerns regarding mesenchymal stem cell (MSC) therapy, MSC-derived exosomes have emerged as an alternative cell-free therapy for myocardial infarction (MI). However, the diffusion of exosomes out of the infarcted heart following injection and the low productivity limit the potential of clinical applications. Here, we developed exosome-mimetic extracellular nanovesicles (NVs) derived from iron oxide nanoparticles (IONPs)-incorporated MSCs (IONP-MSCs). The retention of injected IONP-MSC-derived NVs (IONP-NVs) within the infarcted heart was markedly augmented by magnetic guidance. Furthermore, IONPs significantly increased the levels of therapeutic molecules in IONP-MSCs and IONP-NVs, which can reduce the concern of low exosome productivity. The injection of IONP-NVs into the infarcted heart and magnetic guidance induced an early shift from the inflammation phase to the reparative phase, reduced apoptosis and fibrosis, and enhanced angiogenesis and cardiac function recovery. This approach can enhance the therapeutic potency of an MSC-derived NV therapy
URI
https://pr.ibs.re.kr/handle/8788114/8649
DOI
10.1126/sciadv.aaz0952
ISSN
2375-2548
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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