BROWSE

Related Scientist

Researcher

나노입자 연구단
나노입자 연구단
more info

Ca2+-Dependent Intracellular Drug Delivery System Developed with “Raspberry-Type” Particles-on-a-Particle Comprising Mesoporous Silica Core and α-Synuclein-Coated Gold Nanoparticles

Cited 16 time in webofscience Cited 0 time in scopus
502 Viewed 47 Downloaded
Title
Ca2+-Dependent Intracellular Drug Delivery System Developed with “Raspberry-Type” Particles-on-a-Particle Comprising Mesoporous Silica Core and α-Synuclein-Coated Gold Nanoparticles
Author(s)
Daekyun Lee; Je Won Hong; Chanyoung Park; Hagyeol Lee; Ji Eun Lee; Taeg Hwan Hyeon; Seung R. Paik
Publication Date
2014-09
Journal
ACS NANO, v.8, no.9, pp.8887 - 8895
Publisher
AMER CHEMICAL SOC
Abstract
For the development of an intracellular cargo release system with mesoporous silica nanoparticles (MSN), gold nanoparticles coated with an amyloidogenic protein of R-synuclein were employed to prepare a proteinmediated nanocomposite into the “raspberry-type” particles-on-a-particle (PoP). The PoPs were successfully fabricated only at pH 4.4 by yielding the MSN coverage to 75.3% with 5 nm gold nanoparticles covalently coated with a mutant form of R-synuclein containing a cysteine residue at the C-terminus. The entrapped cargo of rhodamine 6G was shown to be selectively released from PoPs upon exposure to divalent cations including the R-synuclein-specific pathophysiological ligand of Ca2þ. Intracellular uptake of the PoPs preloaded with doxorubicin as an anticancer drug and its subsequent Ca2þ-dependent release were demonstrated with HeLa cells in the presence of intracellular Ca2þ-regulating agents. Therefore, the fabrication of PoPs with the self-interactive protein of R-synuclein is expected to serve as a platform technology for preparation of diversified nanocomposites with various nanoparticles and/or bioactive molecules for eventual applications in the areas of theranostics.
URI
https://pr.ibs.re.kr/handle/8788114/779
ISSN
1936-0851
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
Files in This Item:
lar Drug Delivery System Develped.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse