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Ca2+-Dependent Intracellular Drug Delivery System Developed with “Raspberry-Type” Particles-on-a-Particle Comprising Mesoporous Silica Core and α-Synuclein-Coated Gold Nanoparticles

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Title
Ca2+-Dependent Intracellular Drug Delivery System Developed with “Raspberry-Type” Particles-on-a-Particle Comprising Mesoporous Silica Core and α-Synuclein-Coated Gold Nanoparticles
Author(s)
Daekyun Lee; Je Won Hong; Chanyoung Park; Hagyeol Lee; Ji Eun Lee; Taeg Hwan Hyeon; Seung R. Paik
Subject
R-synuclein . controlled release . drug delivery . mesoporous silica nanoparticle . particles-on-a-particle
Publication Date
2014-09
Journal
ACS NANO, v.8, no.9, pp.8887 - 8895
Publisher
AMER CHEMICAL SOC
Abstract
For the development of an intracellular cargo release system with mesoporous silica nanoparticles (MSN), gold nanoparticles coated with an amyloidogenic protein of R-synuclein were employed to prepare a proteinmediated nanocomposite into the “raspberry-type” particles-on-a-particle (PoP). The PoPs were successfully fabricated only at pH 4.4 by yielding the MSN coverage to 75.3% with 5 nm gold nanoparticles covalently coated with a mutant form of R-synuclein containing a cysteine residue at the C-terminus. The entrapped cargo of rhodamine 6G was shown to be selectively released from PoPs upon exposure to divalent cations including the R-synuclein-specific pathophysiological ligand of Ca2þ. Intracellular uptake of the PoPs preloaded with doxorubicin as an anticancer drug and its subsequent Ca2þ-dependent release were demonstrated with HeLa cells in the presence of intracellular Ca2þ-regulating agents. Therefore, the fabrication of PoPs with the self-interactive protein of R-synuclein is expected to serve as a platform technology for preparation of diversified nanocomposites with various nanoparticles and/or bioactive molecules for eventual applications in the areas of theranostics.
URI
https://pr.ibs.re.kr/handle/8788114/779
DOI
10.1021/nn5034955
ISSN
1936-0851
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
lar Drug Delivery System Develped.pdfDownload

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