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Epitaxially Strained CeO2/Mn3O4 Nanocrystals as an Enhanced Antioxidant for Radioprotection

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Title
Epitaxially Strained CeO2/Mn3O4 Nanocrystals as an Enhanced Antioxidant for Radioprotection
Author(s)
Sang Ihn Han; Sang-woo Lee; Min Gee Cho; Ji Mun Yoo; Myoung Hwan Oh; Beomgyun Jeong; Dokyoon Kim; Ok Kyu Park; Junchul Kim; Eun Namkoong; Jinwoung Jo; Nohyun Lee; Chaehong Lim; Min Soh; Yung-Eun Sung; Jongman Yoo; Kyungpyo Park; Taeghwan Hyeon
Subject
acute radiation syndrome, ; heterostructured nanocrystals, ; lattice strain, ; radioprotectants, ; reactive oxygen species
Publication Date
2020-08
Journal
ADVANCED MATERIALS, v.32, no.31, pp.2001566
Publisher
WILEY-V C H VERLAG GMBH
Abstract
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Nanomaterials with antioxidant properties are promising for treating reactive oxygen species (ROS)-related diseases. However, maintaining efficacy at low doses to minimize toxicity is a critical for clinical applications. Tuning the surface strain of metallic nanoparticles can enhance catalytic reactivity, which has rarely been demonstrated in metal oxide nanomaterials. Here, it is shown that inducing surface strains of CeO2/Mn3O4 nanocrystals produces highly catalytic antioxidants that can protect tissue-resident stem cells from irradiation-induced ROS damage. Manganese ions deposited on the surface of cerium oxide (CeO2) nanocrystals form strained layers of manganese oxide (Mn3O4) islands, increasing the number of oxygen vacancies. CeO2/Mn3O4 nanocrystals show better catalytic activity than CeO2 or Mn3O4 alone and can protect the regenerative capabilities of intestinal stem cells in an organoid model after a lethal dose of irradiation. A small amount of the nanocrystals prevents acute radiation syndrome and increases the survival rate of mice treated with a lethal dose of total body irradiation
URI
https://pr.ibs.re.kr/handle/8788114/7714
DOI
10.1002/adma.202001566
ISSN
0935-9648
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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