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Sensors in heart-on-a-chip: A review on recent progress

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Title
Sensors in heart-on-a-chip: A review on recent progress
Author(s)
Kyoung Won Cho; Wang Hee Lee; Kim B.-S.; Dae-Hyeong Kim
Subject
Biosensors, ; Drug screening, ; Electrophysiology, ; Flexible electronics, ; Heart-on-a-chip
Publication Date
2020-11
Journal
TALANTA, v.219, pp.121269
Publisher
ELSEVIER SCIENCE BV
Abstract
© 2020 Elsevier B.V.Drug-induced cardiotoxicity is a major problem in drug discovery. Many approaches to efficient drug screening have been developed, including animal testing in vivo and cell testing in vitro. However, due to intrinsic difference between species, animal-based toxicity testing cannot comprehensively determine the potential side effects in subsequent human clinical trials. Furthermore, conventional in vitro assays are costly and labour-intensive, and require numerous tests. Therefore, it would be necessary to develop heart-on-a-chips made with advanced materials and soft bioelectronic fabrication techniques that offer fast, efficient, and accurate sensing of cardiac cells’ behaviors in vitro. In this review, we introduce two key sensing methods in heart-on-a-chip for physical and electrical measurements. First, optical (e.g., direct and calcium imaging, and fluorescent, laser-based, and colorimetric sensing) and electrical (e.g., impedance, strain, and crack sensing) sensors that record the contractility of cardiomyocytes are reviewed. Subsequently, various sensors composed of rigid planar/three-dimensional electrodes, soft/flexible electronics, and nanomaterial-based transistors to monitor extracellular and intracellular electrophysiological potentials are discussed. A brief overview of future technology and comments on the current challenges conclude the review
URI
https://pr.ibs.re.kr/handle/8788114/7572
DOI
10.1016/j.talanta.2020.121269
ISSN
0039-9140
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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