Sensory receptors in human skin transmit a wealth of tactile and thermal signals from
external environments to the brain. Despite advances in our understanding of mechano- and
thermosensation, replication of these unique sensory characteristics in artificial skin and
prosthetics remains challenging. Recent efforts to develop smart prosthetics, which exploit
rigid and/or semi-flexible pressure, strain and temperature sensors, provide promising routes
for sensor-laden bionic systems, but with limited stretchability, detection range and spatiotemporal
resolution. Here we demonstrate smart prosthetic skin instrumented with ultrathin,
single crystalline silicon nanoribbon strain, pressure and temperature sensor arrays as well as
associated humidity sensors, electroresistive heaters and stretchable multi-electrode arrays
for nerve stimulation. This collection of stretchable sensors and actuators facilitate highly
localized mechanical and thermal skin-like perception in response to external stimuli, thus
providing unique opportunities for emerging classes of prostheses and peripheral nervous
system interface technologies.