BROWSE

Related Scientist

Researcher

김종진
복잡계 자기조립 연구단
more info

Multimodal Imaging Probe Development for Pancreatic beta Cells: From Fluorescence to PET

Cited 0 time in webofscience Cited 0 time in scopus
9 Viewed 2 Downloaded
Title
Multimodal Imaging Probe Development for Pancreatic beta Cells: From Fluorescence to PET
Author(s)
Kang, NY; Lee, JY; Lee, SH; Song, IH; Hwang, YH; Kim, MJ; Phue, WH; Agrawalla, BK; Wan, SYD; Lalic, J; Park, SJ; Jong-Jin Kim; Haw-Young Kwon; Im, SH; Bae, MA; Ahn, JH; Lim, CS; Teo, AKK; Park, S; Kim, SE; Lee, BC; Lee, DY; Young-Tae Chang
Publication Date
2020-02
Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.142, no.7, pp.3430 - 3439
Publisher
AMER CHEMICAL SOC
Abstract
Pancreatic beta cells are responsible for insulin secretion and are important for glucose regulation in a healthy body and diabetic disease patient without prelabeling of islets. While the conventional biomarkers for diabetes have been glucose and insulin concentrations in the blood, the direct determination of the pancreatic beta cell mass would provide critical information for the disease status and progression. By combining fluorination and diversity-oriented fluorescence library strategy, we have developed a multimodal pancreatic beta cell probe PiF for both fluorescence and for PET (positron emission tomography). By simple tail vein injection, PiF stains pancreatic beta cells specifically and allows intraoperative fluorescent imaging of pancreatic islets. PiF-injected pancreatic tissue even facilitated an antibody-free islet analysis within 2 h, dramatically accelerating the day-long histological procedure without any fixing and dehydration step. Not only islets in the pancreas but also the low background of PiF in the liver allowed us to monitor the intraportal transplanted islets, which is the first in vivo visualization of transplanted human islets without a prelabeling of the islets. Finally, we could replace the built-in fluorine atom in PiF with radioactive 18F and successfully demonstrate in situ PET imaging for pancreatic islets. © 2020 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/7244
ISSN
0002-7863
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
Files in This Item:
jacs.9b11173.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse