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kim,jongjin
복잡계자기조립연구단
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Multimodal Imaging Probe Development for Pancreatic beta Cells: From Fluorescence to PET

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dc.contributor.authorKang, NY-
dc.contributor.authorLee, JY-
dc.contributor.authorLee, SH-
dc.contributor.authorSong, IH-
dc.contributor.authorHwang, YH-
dc.contributor.authorKim, MJ-
dc.contributor.authorPhue, WH-
dc.contributor.authorAgrawalla, BK-
dc.contributor.authorWan, SYD-
dc.contributor.authorLalic, J-
dc.contributor.authorPark, SJ-
dc.contributor.authorJong-Jin Kim-
dc.contributor.authorHaw-Young Kwon-
dc.contributor.authorIm, SH-
dc.contributor.authorBae, MA-
dc.contributor.authorAhn, JH-
dc.contributor.authorLim, CS-
dc.contributor.authorTeo, AKK-
dc.contributor.authorPark, S-
dc.contributor.authorKim, SE-
dc.contributor.authorLee, BC-
dc.contributor.authorLee, DY-
dc.contributor.authorYoung-Tae Chang-
dc.date.available2020-10-14T08:14:54Z-
dc.date.created2020-03-17-
dc.date.issued2020-02-
dc.identifier.issn0002-7863-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/7244-
dc.description.abstractPancreatic beta cells are responsible for insulin secretion and are important for glucose regulation in a healthy body and diabetic disease patient without prelabeling of islets. While the conventional biomarkers for diabetes have been glucose and insulin concentrations in the blood, the direct determination of the pancreatic beta cell mass would provide critical information for the disease status and progression. By combining fluorination and diversity-oriented fluorescence library strategy, we have developed a multimodal pancreatic beta cell probe PiF for both fluorescence and for PET (positron emission tomography). By simple tail vein injection, PiF stains pancreatic beta cells specifically and allows intraoperative fluorescent imaging of pancreatic islets. PiF-injected pancreatic tissue even facilitated an antibody-free islet analysis within 2 h, dramatically accelerating the day-long histological procedure without any fixing and dehydration step. Not only islets in the pancreas but also the low background of PiF in the liver allowed us to monitor the intraportal transplanted islets, which is the first in vivo visualization of transplanted human islets without a prelabeling of the islets. Finally, we could replace the built-in fluorine atom in PiF with radioactive 18F and successfully demonstrate in situ PET imaging for pancreatic islets. © 2020 American Chemical Society-
dc.description.uri1-
dc.language영어-
dc.publisherAMER CHEMICAL SOC-
dc.titleMultimodal Imaging Probe Development for Pancreatic beta Cells: From Fluorescence to PET-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000515214000025-
dc.identifier.scopusid2-s2.0-85079758652-
dc.identifier.rimsid71549-
dc.contributor.affiliatedAuthorJong-Jin Kim-
dc.contributor.affiliatedAuthorHaw-Young Kwon-
dc.contributor.affiliatedAuthorYoung-Tae Chang-
dc.identifier.doi10.1021/jacs.9b11173-
dc.identifier.bibliographicCitationJOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.142, no.7, pp.3430 - 3439-
dc.citation.titleJOURNAL OF THE AMERICAN CHEMICAL SOCIETY-
dc.citation.volume142-
dc.citation.number7-
dc.citation.startPage3430-
dc.citation.endPage3439-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusVISUALIZATION-
dc.subject.keywordPlusPREVENTION-
dc.subject.keywordPlusPROSPECTS-
dc.subject.keywordPlusHEALTHY-
dc.subject.keywordPlusLIBRARY-
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
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