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Yoo, Je Joong
복잡계 자기조립 연구단
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Hierarchical Self-Assembly of Poly-Pseudorotaxanes into Artificial Microtubules

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Title
Hierarchical Self-Assembly of Poly-Pseudorotaxanes into Artificial Microtubules
Author(s)
Hwang, W; Jejoong Yoo; In-Chul Hwang; Lee, J; Young Ho Ko; Hyun Woo Kim; Kim, Y; Lee, Y; Moon Young Hur; Kyeng Min Park; Seo, J; Kangkyun Baek; Kimoon Kim
Subject
host-guest systems, ; microtubules, ; rotaxanes, ; self-assembly, ; supramolecular chemistry
Publication Date
2020-02
Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.59, no.9, pp.3460 - 3464
Publisher
WILEY-V C H VERLAG GMBH
Abstract
Hierarchical self-assembly of building blocks over multiple length scales is ubiquitous in living organisms. Microtubules are one of the principal cellular components formed by hierarchical self-assembly of nanometer-sized tubulin heterodimers into protofilaments, which then associate to form micron-length-scale, multi-stranded tubes. This peculiar biological process is now mimicked with a fully synthetic molecule, which forms a 1:1 host-guest complex with cucurbit[7]uril as a globular building block, and then polymerizes into linear poly-pseudorotaxanes that associate laterally with each other in a self-shape-complementary manner to form a tubular structure with a length over tens of micrometers. Molecular dynamic simulations suggest that the tubular assembly consists of eight poly-pseudorotaxanes that wind together to form a 4.5 nm wide multi-stranded tubule. 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
URI
https://pr.ibs.re.kr/handle/8788114/7013
DOI
10.1002/anie.201913384
ISSN
1433-7851
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
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