BROWSE

Related Scientist

Researcher

나노입자 연구단
나노입자 연구단
more info

Toxicological Risk Assessments of Iron Oxide Nanocluster- and Gadolinium-Based T1MRI Contrast Agents in Renal Failure Rats

Cited 0 time in webofscience Cited 0 time in scopus
30 Viewed 4 Downloaded
Title
Toxicological Risk Assessments of Iron Oxide Nanocluster- and Gadolinium-Based T1MRI Contrast Agents in Renal Failure Rats
Author(s)
Weng Q.; Hu X.; Zheng J.; Xia F.; Wang N.; Liao H.; Liu Y.; Dokyoon Kim; Jianan Liu; Li F.; He Q.; Yang B.; Chen C.; Taeghwan Hyeon; Ling D.
Publication Date
2019-06
Journal
ACS NANO, v.13, no.6, pp.6801 - 6812
Publisher
AMER CHEMICAL SOC
Abstract
© 2019 American Chemical Society.Gadolinium-based contrast agents (GBCAs) are widely used for T1-weighted magnetic resonance imaging (MRI) in clinic diagnosis. However, a major drawback of GBCAs is that they can increase the toxicological risk of nephrogenic systemic fibrosis (NSF) in patients with advanced renal dysfunction. Hence, safer alternatives to GBCAs are currently in demand, especially for patients with renal diseases. Here we investigated the potential of polyethylene glycol (PEG)-stabilized iron oxide nanoclusters (IONCs) as biocompatible T1MRI contrast agents and systematically evaluated their NSF-related risk in rats with renal failure. We profiled the distribution, excretion, histopathological alterations, and fibrotic gene expressions after administration of IONCs and GBCAs. Our results showed that, compared with GBCAs, IONCs exhibited dramatically improved biosafety and a much lower risk of causing NSF, suggesting the feasibility of substituting GBCAs with IONCs in clinical MRI diagnosis of patients with renal diseases
URI
https://pr.ibs.re.kr/handle/8788114/6917
ISSN
1936-0851
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
Files in This Item:
4.toxicologic.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse