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나노입자 연구단
나노입자 연구단
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Ferrimagnetic Nanochains-Based Mesenchymal Stem Cell Engineering for Highly Efficient Post-Stroke Recovery

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Title
Ferrimagnetic Nanochains-Based Mesenchymal Stem Cell Engineering for Highly Efficient Post-Stroke Recovery
Author(s)
Zhang T.; Li F.; Xu Q.; Wang Q.; Jiang X.; Liang Z.; Liao H.; Kong X.; Jianan Liu; Wu H.; Zhang D.; An C.; Dong L.; Lu Y.; Cao H.; Dokyoon Kim; Sun J.; Taeghwan Hyeon; Gao J.; Ling D.
Publication Date
2019-06
Journal
ADVANCED FUNCTIONAL MATERIALS, v.29, no.24, pp.1900603 -
Publisher
WILEY-V C H VERLAG GMBH
Abstract
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Unsatisfactory post-stroke recovery has long been a negative factor in the prognosis of ischemic stroke due to the lack of pharmacological treatments. Mesenchymal stem cells (MSCs)-based therapy has recently emerged as a promising strategy redefining stroke treatment; however, its effectiveness has been largely restricted by insufficient therapeutic gene expression and inadequate cell numbers in the ischemic cerebrum. Herein, a non-viral and magnetic field-independent gene transfection approach is reported, using magnetosome-like ferrimagnetic iron oxide nanochains (MFIONs), to genetically engineer MSCs for highly efficient post-stroke recovery. The 1D MFIONs show efficient cellular uptake by MSCs, which results in highly efficient genetic engineering of MSCs to overexpress brain-derived neurotrophic factor for treating ischemic cerebrum. Moreover, the internalized MFIONs promote the homing of MSCs to the ischemic cerebrum by upregulating CXCR4. Consequently, a pronounced recovery from ischemic stroke is achieved using MFION-engineered MSCs in a mouse model
URI
https://pr.ibs.re.kr/handle/8788114/6913
ISSN
1616-301X
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
Files in This Item:
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