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나노입자 연구단
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Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors

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Title
Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors
Author(s)
Jongha Lee; Hye Rim Cho; Gi Doo Cha; Hyunseon Seo; Lee, S; Park, CK; Kim, JW; Qiao, ST; Wang, L; Dayoung Kang; Taegyu Kang; Ichikawa, T; Jonghoon Kim; Hakyong Lee; Woongchan Lee; Kim, S; Lee, ST; Lu, NS; Taeghwan Hyeon; Seung Hong Choi; Dae-Hyeong Kim
Publication Date
2019-11
Journal
NATURE COMMUNICATIONS, v.10, no., pp.5205 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Implantation of biodegradable wafers near the brain surgery site to deliver anti-cancer agents which target residual tumor cells by bypassing the blood-brain barrier has been a promising method for brain tumor treatment. However, further improvement in the prognosis is still necessary. We herein present novel materials and device technologies for drug delivery to brain tumors, i.e., a flexible, sticky, and biodegradable drug-loaded patch integrated with wireless electronics for controlled intracranial drug delivery through mild-thermic actuation. The flexible and bifacially-designed sticky/hydrophobic device allows conformal adhesion on the brain surgery site and provides spatially-controlled and temporarily-extended drug delivery to brain tumors while minimizing unintended drug leakage to the cerebrospinal fluid. Biodegradation of the entire device minimizes potential neurological side-effects. Application of the device to the mouse model confirms tumor volume suppression and improved survival rate. Demonstration in a large animal model (canine model) exhibited its potential for human application. © The Author(s) 2019
URI
https://pr.ibs.re.kr/handle/8788114/6802
ISSN
2041-1723
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
Files in This Item:
4 Nature Communications.pdfDownload

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