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Locally Activating TrkB Receptor Generates Actin Waves and Specifies Axonal Fate

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Title
Locally Activating TrkB Receptor Generates Actin Waves and Specifies Axonal Fate
Author(s)
Doyeon Woo; Yeji Seo; Hyunjin Jung; Sungsoo Kim; Nury Kim; Sang-Min Park; Heeyoung Lee; Sangkyu Lee; Kwang-Hyun Cho; Won Do Heo
Publication Date
2019-12
Journal
CELL CHEMICAL BIOLOGY, v.26, no.12, pp.1652 - +
Publisher
CELL PRESS
Abstract
Actin waves are filamentous actin (F-actin)-rich structures that initiate in the somato-neuritic area and move toward neurite ends. The upstream cues that initiate actin waves are poorly understood. Here, using an optogenetic approach (Opto-cytTrkB), we found that local activation of the TrkB receptor around the neurite end initiates actin waves and triggers neurite elongation. During actin wave generation, locally activated TrkB signaling in the distal neurite was functionally connected with preferentially localized Rac1 and its signaling pathways in the proximal region. Moreover, TrkB activity changed the location of ankyrinG––the master organizer of the axonal initial segment-and initiated the stimulated neurite to acquire axonal characteristics. Taken together, these findings suggest that local Opto-cytTrkB activation switches the fate from minor to major axonal neurite during neuronal polarization by generating actin waves.C. 2019 Elsevier Ltd.
URI
https://pr.ibs.re.kr/handle/8788114/6694
ISSN
2451-9448
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Social Neuroscience Group(사회성 뇌과학 그룹) > Journal Papers (저널논문)
Center for Cognition and Sociality(인지 및 사회성 연구단) > Journal Papers (저널논문)
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201912 Cell chemical Biology.pdfDownload

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