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나노입자 연구단
나노입자 연구단
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Prognostic Predictions for Patients with Glioblastoma after Standard Treatment: Application of Contrast Leakage Information from DSC-MRI within Nonenhancing FLAIR High-Signal-Intensity Lesions

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Title
Prognostic Predictions for Patients with Glioblastoma after Standard Treatment: Application of Contrast Leakage Information from DSC-MRI within Nonenhancing FLAIR High-Signal-Intensity Lesions
Author(s)
Kim, SH; Cho, KH; Seung Hong Choi; Kim, TM; Park, CK; Park, SH; Won, JK; Kim, IH; Lee, ST
Publication Date
2019-12
Journal
AMERICAN JOURNAL OF NEURORADIOLOGY, v.40, no.12, pp.2052 - 2058
Publisher
AMER SOC NEURORADIOLOGY
Abstract
BACKGROUND AND PURPOSE: Attempts have been made to quantify the microvascular leakiness of glioblastomas and use it as an imaging biomarker to predict the prognosis of the tumor. The purpose of our study was to evaluate whether the extraction fraction value from DSC-MR imaging within nonenhancing FLAIR hyperintense lesions was a better prognostic imaging biomarker than dynamic contrast-enhanced MR imaging parameters for patients with glioblastoma. MATERIALS AND METHODS: A total of 102 patients with glioblastoma who received a preoperative dynamic contrast-enhanced MR imaging and DSC-MR imaging were included in this retrospective study. Patients were classified into the progression (n?=?87) or nonprogression (n?=?15) groups at 24?months after surgery. We extracted the means and 95th percentile values for the contrast leakage information parameters from both modalities within the nonenhancing FLAIR high-signal-intensity lesions. RESULTS: The extraction fraction 95th percentile value was higher in the progression-free survival group of >24?months than at ?24?months. The median progression-free survival of the group with an extraction fraction 95th percentile value of >13.32 was 17?months, whereas that of the group of ?13.32 was 12?months. In addition, it was an independent predictor variable for progression-free survival in the patients regardless of their ages and genetic information. CONCLUSIONS: The extraction fraction 95th percentile value was the only independent parameter for prognostic prediction in patients with glioblastoma among the contrast leakage information, which has no statistically significant correlations with the DCE-MR imaging parameters
URI
https://pr.ibs.re.kr/handle/8788114/6687
ISSN
0195-6108
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
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