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Tools for Bioimaging Pancreatic β Cells in Diabetes

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Title
Tools for Bioimaging Pancreatic β Cells in Diabetes
Author(s)
Nam-Young Kang; Andreas Alvin Purnomo Soetedjo; Nur Shabrina Amirruddin; Young Tae Chang; Olof Eriksson; Adrian Kee Keong Teo
Publication Date
2019-08
Journal
TRENDS IN MOLECULAR MEDICINE, v.25, no.8, pp.708 - 722
Publisher
ELSEVIER SCI LTD
Abstract
© 2019 Elsevier LtdWhen diabetes is diagnosed, the majority of insulin-secreting pancreatic β cells are already dysfunctional or destroyed. This β cell dysfunction/destruction usually takes place over many years, making timely detection and clinical intervention difficult. For this reason, there is immense interest in developing tools to bioimage β cell mass and/or function noninvasively to facilitate early diagnosis of diabetes as well as to assist the development of novel antidiabetic therapies. Recent years have brought significant progress in β cell imaging that is now inching towards clinical applicability. We explore here the need to bioimage human β cells noninvasively in various types of diabetes, and we discuss current and emerging tools for bioimaging β cells. Further developments in this field are expected to facilitate β cell imaging in diabetes
URI
https://pr.ibs.re.kr/handle/8788114/6278
ISSN
1471-4914
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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