An Implantable Wireless Interstitial Pressure Sensor With Integrated Guyton Chamber: in vivo Study in Solid Tumors

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Title
An Implantable Wireless Interstitial Pressure Sensor With Integrated Guyton Chamber: in vivo Study in Solid Tumors
Author(s)
Seung Hyun Song; Albert Kim; Marcus Brown; Chaeyong Jung; S. Ko; Babak Ziaie
Publication Date
2016-11
Journal
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, v.63, no.11, pp.2273 - 2277
Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
Abstract
A wireless implantable interstitial fluid pressure (IFP) sensor with an integrated Guyton chamber is presented. This implantable device enables noninvasive and continuous measurements of IFP. The Guyton chamber allows for an accurate measurement of IFP without the interference from various cellular/tissue components. The sensor consists of a coil, an air chamber, a silicone membrane embedded with a nickel plate, and a Guyton chamber. The fabricated device is 3 mm in diameter and 1 mm in thickness. The sensor shows a linear response to the pressure with a sensitivity of 60 kHz/mmHg and a resolution of 1 mmHg. Experiments in human prostate cancer tumors grown in mice confirm the sensor's capability to operate in vivo and provide continuous wireless measurement of IFP, a surrogate parameter indicating the "window of opportunity" for delivering chemo-and radio-therapeutic agents. © 2016 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission.
URI
https://pr.ibs.re.kr/handle/8788114/6033
ISSN
0018-9294
Appears in Collections:
Center for Integrated Nanostructure Physics(나노구조물리 연구단) > Journal Papers (저널논문)
Files in This Item:
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