BROWSE

Related Scientist

Researcher

홍선표
혈관 연구단
more info

Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages

Cited 0 time in webofscience Cited 0 time in scopus
113 Viewed 25 Downloaded
Title
Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages
Author(s)
Suh S.; Choe K.; Seon Pyo Hong; Jeong S.-H.; Mäkinen T.; Kwang Soon Kim; Alitalo K.; Charles D Surh; Gou Young Koh; Joo-Hye Song
Publication Date
2019-04
Journal
EMBO REPORTS, v.20, no.4, pp.e46927 -
Publisher
WILEY
Abstract
A lacteal is a blunt-ended, long, tube-like lymphatic vessel located in the center of each intestinal villus that provides a unique route for drainage of absorbed lipids from the small intestine. However, key regulators for maintaining lacteal integrity are poorly understood. Here, we explore whether and how the gut microbiota regulates lacteal integrity. Germ depletion by antibiotic treatment triggers lacteal regression during adulthood and delays lacteal maturation during the postnatal period. In accordance with compromised lipid absorption, the button-like junction between lymphatic endothelial cells, which is ultrastructurally open to permit free entry of dietary lipids into lacteals, is significantly reduced in lacteals of germ-depleted mice. Lacteal defects are also found in germ-free mice, but conventionalization of germ-free mice leads to normalization of lacteals. Mechanistically, VEGF-C secreted from villus macrophages upon MyD88-dependent recognition of microbes and their products is a main factor in lacteal integrity. Collectively, we conclude that the gut microbiota is a crucial regulator for lacteal integrity by endowing its unique microenvironment and regulating villus macrophages in small intestine. © 2019 The Author
URI
https://pr.ibs.re.kr/handle/8788114/5863
ISSN
1469-221X
Appears in Collections:
Center for Vascular Research(혈관 연구단) > Journal Papers (저널논문)
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
Files in This Item:
embr.201846927.full.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse