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Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages

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dc.contributor.authorSuh S.-
dc.contributor.authorChoe K.-
dc.contributor.authorSeon Pyo Hong-
dc.contributor.authorJeong S.-H.-
dc.contributor.authorMäkinen T.-
dc.contributor.authorKwang Soon Kim-
dc.contributor.authorAlitalo K.-
dc.contributor.authorCharles D Surh-
dc.contributor.authorGou Young Koh-
dc.contributor.authorJoo-Hye Song-
dc.date.available2019-07-19T05:37:29Z-
dc.date.created2019-03-19-
dc.date.issued2019-04-
dc.identifier.issn1469-221X-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/5863-
dc.description.abstractA lacteal is a blunt-ended, long, tube-like lymphatic vessel located in the center of each intestinal villus that provides a unique route for drainage of absorbed lipids from the small intestine. However, key regulators for maintaining lacteal integrity are poorly understood. Here, we explore whether and how the gut microbiota regulates lacteal integrity. Germ depletion by antibiotic treatment triggers lacteal regression during adulthood and delays lacteal maturation during the postnatal period. In accordance with compromised lipid absorption, the button-like junction between lymphatic endothelial cells, which is ultrastructurally open to permit free entry of dietary lipids into lacteals, is significantly reduced in lacteals of germ-depleted mice. Lacteal defects are also found in germ-free mice, but conventionalization of germ-free mice leads to normalization of lacteals. Mechanistically, VEGF-C secreted from villus macrophages upon MyD88-dependent recognition of microbes and their products is a main factor in lacteal integrity. Collectively, we conclude that the gut microbiota is a crucial regulator for lacteal integrity by endowing its unique microenvironment and regulating villus macrophages in small intestine. © 2019 The Author-
dc.languageENG-
dc.publisherWILEY-
dc.titleGut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages-
dc.typeArticle-
dc.type.rimsA-
dc.identifier.wosid000463235300015-
dc.identifier.scopusid2-s2.0-85061798976-
dc.contributor.affiliatedAuthorSeon Pyo Hong-
dc.contributor.affiliatedAuthorKwang Soon Kim-
dc.contributor.affiliatedAuthorCharles D Surh-
dc.contributor.affiliatedAuthorGou Young Koh-
dc.contributor.affiliatedAuthorJoo-Hye Song-
dc.identifier.bibliographicCitationEMBO REPORTS, v.20, no.4, pp.e46927 --
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
Center for Vascular Research(혈관 연구단) > Journal Papers (저널논문)
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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