Guest-responsive, Non-proteolytic Harvest of a Cell-sheet using Controllable Host-guest Chemistry

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Title
Guest-responsive, Non-proteolytic Harvest of a Cell-sheet using Controllable Host-guest Chemistry
Author(s)
Kyeng Min Park; Annadka Shrinidhi; James Murray; Kimoon Kim
Publication Date
2018-04
Journal
ISRAEL JOURNAL OF CHEMISTRY, v.58, no.3-4, pp.461 - 465
Publisher
WILEY-V C H VERLAG GMBH
Abstract
A new non-proteolytic method to harvest a cell-sheet was demonstrated using controllable host-guest interactions which can be dissociated by treating a strong guest on demand. Fibroblast cells (NIH3T3) were grown to confluence on a 1,6-diammoniumhexane conjugated hyaluronic acid (DAH-HA) polymer which was anchored to a cucurbit[7]uril (CB[7]) surface using the host-guest interaction between DAH and CB[7]. Treating with a strong guest allowed the cultured cells to be detached from the surface as a free standing sheet. This approach demonstrated the great potential of controllable host-guest chemistry as a novel tool for non-proteolytic harvesting of cell-sheets useful for regenerative therapy. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
URI
https://pr.ibs.re.kr/handle/8788114/5789
ISSN
0021-2148
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
Files in This Item:
300. K. M. Park, lsr. J. Chem., 2018.pdfDownload

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