BROWSE

Related Scientist

Researcher

박경민
복잡계 자기조립 연구단
more info

Mono-allyloxylated Cucurbit[7]uril Acts as an Unconventional Amphiphile To Form Light-Responsive Vesicles

Cited 0 time in webofscience Cited 0 time in scopus
20 Viewed 3 Downloaded
Title
Mono-allyloxylated Cucurbit[7]uril Acts as an Unconventional Amphiphile To Form Light-Responsive Vesicles
Author(s)
Kyeng Min Park; Kangkyun Baek; Young Ho Ko; Annadka Shrinidhi; James Murray; Jang, WH; Kim, KH; Lee, JS; Jejoong Yoo; Kim, S; Kimoon Kim
Publication Date
2018-03
Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.57, no.12, pp.3132 - 3136
Publisher
WILEY-V C H VERLAG GMBH
Abstract
Serendipitously, mono-allyloxylated cucurbit[7]uril (AO(1)CB[7]) was discovered to act as an unconventional amphiphile which self-assembles into light-responsive vesicles (AO(1)CB[7]VC) in water. Although the mono-allyloxy group, directly tethered on the periphery of CB[7], is much shorter (C4) than the hydrophobic tails of conventional amphiphiles, it played an important role in vesicle formation. Light-activated transformation of the allyloxy group by conjugation with glutathione was exploited as a remote tool to disrupt the vesicle. The vesicle showed on-demand release of cargo upon irradiation by a laser, after they were internalized into cancer cells. This result demonstrated the potential of AO(1)CB[7]VC as a new type of light-responsive intracellular delivery vehicle for the release of therapeutic cargo, within cells, on demand T 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
URI
https://pr.ibs.re.kr/handle/8788114/5460
ISSN
1433-7851
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
Files in This Item:
3.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse