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나노입자 연구단
나노입자 연구단
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Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics

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Title
Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics
Author(s)
Shuaifei Wang; Fangyuan Li; Ruirui Qiao; Xi Hu; Hongwei Liao; Lumin Chen; Jiahe Wu; Haibin Wu; Meng Zhao; Jianan Liu; Rui Chen; Xibo Ma; Dokyoon Kim; Jihong Sun; Thomas P. Davis; Chunying Chen; Jie Tian; Taeghwan Hyeon; Daishun Ling
Publication Date
2018-12
Journal
ACS NANO, v.12, no., pp.12380 - 12392
Publisher
AMER CHEMICAL SOC
Abstract
Ferroptosis, an iron-based cell-death pathway, has recently attracted great attention owing to its effectiveness in killing cancer cells. Previous investigations focused on the development of iron-based nanomaterials to induce ferroptosis in cancer cells by the up-regulation of reactive oxygen species (ROS) generated by the wellknown Fenton reaction. Herein, we report a ferroptosisinducing agent based on arginine-rich manganese silicate nanobubbles (AMSNs) that possess highly efficient glutathione (GSH) depletion ability and thereby induce ferroptosis by the inactivation of glutathione-dependent peroxidases 4 (GPX4). The AMSNs were synthesized via a one-pot reaction with arginine (Arg) as the surface ligand for tumor homing. Subsequently, a significant tumor suppression effect can be achieved by GSH depletion-induced ferroptosis. Moreover, the degradation of AMSNs during the GSH depletion contributed to T1-weighted magnetic resonance imaging (MRI) enhancement as well as on-demand chemotherapeutic drug release for synergistic cancer therapy. We anticipate that the GSH-depletion-induced ferroptosis strategy by using manganese-based nanomaterials would provide insights in designing nanomedicines for tumor-targeted theranostics. © 2018 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/5389
ISSN
1936-0851
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
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