Advances in the design of cell-permeable fluorescent probes for applications in live cell imaging

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Title
Advances in the design of cell-permeable fluorescent probes for applications in live cell imaging
Author(s)
Samira Husen Alamudi; Young-Tae Chang
Publication Date
2018-12
Journal
CHEMICAL COMMUNICATIONS, v.54, no.97, pp.13641 - 13653
Publisher
ROYAL SOC CHEMISTRY
Abstract
Small fluorescent molecules have been an important tool for fluorescence-based imaging, thanks to their technical simplicity, sensitivity and structural flexibility. However, probing specific intracellular systems with a small fluorescent molecule is not an easy task owing to the intricate nature of the cells. Ideal imaging probes should be highly permeable and be without background noise to allow undisrupted observations. These probes will unquestionably be more advantageous for interrogating intracellular architectures and dynamics without compromising the cellular integrity, and could therefore be applied for applications in the native cellular environment. This review will highlight the advances in design strategies for cell-permeable fluorescent probes through a diversity-oriented fluorescence library approach and rational design via computational-aided predictive models. Here, we discuss a series of cell-permeable probe applications for imaging specific cell types and intracellular biomolecules, as well as the cellular environment. c. 2018 The Royal Society of Chemistry
URI
https://pr.ibs.re.kr/handle/8788114/5319
ISSN
1359-7345
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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