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나노입자 연구단
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Application of synthetic MRI for direct measurement of magnetic resonance relaxation time and tumor volume at multiple time points after contrast administration: Preliminary results in patients with brain metastasis

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Title
Application of synthetic MRI for direct measurement of magnetic resonance relaxation time and tumor volume at multiple time points after contrast administration: Preliminary results in patients with brain metastasis
Author(s)
Kang K.M.; Seung Hong Choi; Hwang M.; Yoo R.-E.; Yun T.J.; Kim J.-H.; Sohn C.-H.
Publication Date
2018-07
Journal
KOREAN JOURNAL OF RADIOLOGY, v.19, no.4, pp.783 - 791
Publisher
KOREAN RADIOLOGICAL SOC
Abstract
Objective: The purpose of this study was to investigate the time-dependent effects of contrast medium on multi-dynamic, multi-echo (MDME) sequence in patients with brain metastases. Materials and Methods: This study included 7 patients with 15 brain metastases who underwent magnetic resonance (MR) examination which included MDME sequences at 1 minute, 10 minutes and 20 minutes after contrast injection. Two volumes of interests, covering an entire tumor (whole tumor) and the enhancing portion of the tumor, were derived from post-contrast synthetic T1-weighted images. Statistical comparisons were performed for three different time delays for histogram parameters of the longitudinal relaxation rate (R1) and the transverse relaxation rate (R2), and lesion volumes. Results: The mean and the median of R1 and the mean of R2 in both the whole tumor and the inner enhancing portion were larger on the 10 minutes delayed images than on the 1 minute or 20 minutes delayed images (mean of R1 in the whole tumor on the 1 minute, 10 minutes, and 20 minutes delayed images: 1.26 ms, 1.39 ms, and 1.37 ms; mean of R1 in the inner enhancing portion: 1.43 ms, 1.53 ms and 1.44 ms; all p < 0.017). The volumes of the whole tumor and the inner enhancing portion were significantly larger in the 10 minutes and 20 minutes delayed images than on the 1 minute delayed images (all p < 0.017). Conclusion: Magnetic resonance relaxation times and the volumes of the whole tumor and the inner enhancing portion were measured larger on the 10 minutes or 20 minutes delayed images than on the 1 minute delayed images. The MDME sequence immediately after contrast injection cannot fully reflect the effects of gadolinium-based contrast agent leakage in the tissue. © 2018 The Korean Society of Radiology
URI
https://pr.ibs.re.kr/handle/8788114/5242
ISSN
1229-6929
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
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