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면역미생물공생연구단
면역 미생물 공생 연구단
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Spontaneous Proliferation of CD4(+) T Cells in RAG-Deficient Hosts Promotes Antigen-Independent but IL-2-Dependent Strong Proliferative Response of Naive CD8(+) T Cells

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Title
Spontaneous Proliferation of CD4(+) T Cells in RAG-Deficient Hosts Promotes Antigen-Independent but IL-2-Dependent Strong Proliferative Response of Naive CD8(+) T Cells
Author(s)
Juhee Kim; Jun Young Lee; Kyungjin Cho; Sung-Wook Hong; Kwang Soon Kim; Jonathan Sprent; Sin-Hyeog Im; Charles D. Surh; Jae-Ho Cho
Publication Date
2018-08
Journal
FRONTIERS IN IMMUNOLOGY, v.9, no., pp.1907 -
Publisher
FRONTIERS MEDIA SA
Abstract
The fast and intense proliferative responses have been well documented for naive T cells adoptively transferred into chronic lymphopenic hosts. This response known as spontaneous proliferation (SP), unlike antigen-independent lymphopenia-induced proliferation (LIP), is driven in a manner dependent on antigens derived from commensal microbiota. However, the precise nature of the SP response and its impact on homeostasis and function for T cells rapidly responding under this lymphopenic condition are still unclear. Here we demonstrate that, when naive T cells were adoptively transferred into specific pathogen-free (SPF) but not germ-free (GF) RAG(-/-) hosts, the SP response of these cells substantially affects the intensity and tempo of the responding T cells undergoing LIP. Therefore, the resulting response of these cells in SPF RAG(-/-) hosts was faster and stronger than the typical LIP response observed in irradiated B6 hosts. Although the intensity and tempo of such augmented LIP in SPF RAG(-/-) hosts were analogous to those of antigen-dependent SP, the former was independent of antigenic stimulation but most importantly, dependent on IL-2. Similar observations were also apparent in other acute lymphopenic settings where antigen-dependent T cell activation can strongly occur and induce sufficient levels of IL-2 production. Consequently, the resulting T cells undergoing IL-2-driven strong proliferative responses showed the ability to differentiate into functional effector and memory cells that can control infectious pathogens. These findings therefore reveal previously unappreciated role of IL-2 in driving the intense form of T cell proliferative responses in chronic lymphopenic hosts. ⓒ 2007 - 2018 Frontiers Media S.A. All Rights Reserved
URI
https://pr.ibs.re.kr/handle/8788114/5220
ISSN
1664-3224
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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