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첨단연성물질 연구단
첨단연성물질 연구단
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Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo

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Title
Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo
Author(s)
Sabil Huda; Bettina Weigelin; Katarina Wolf; Konstantin V. Tretiakov; Konstantin Polev; Gary Wilk; Masatomo Iwasa; Fateme S. Emami; Jakub W. Narojczyk; Michal Banaszak; Siowling Soh; Didzis Pilans; Amir Vahid; Monika Makurath; Peter Friedl; Gary G. Borisy; Kristiana Kandere-Grzybowska; Bartosz A. Grzybowski
Publication Date
2018-10
Journal
NATURE COMMUNICATIONS, v.9, no.1, pp.4539 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Metastatic cancer cells differ from their non-metastatic counterparts not only in terms of molecular composition and genetics, but also by the very strategy they employ for locomotion. Here, we analyzed large-scale statistics for cells migrating on linear microtracks to show that metastatic cancer cells follow a qualitatively different movement strategy than their non-invasive counterparts. The trajectories of metastatic cells display clusters of small steps that are interspersed with long “flights”. Such movements are characterized by heavy-tailed, truncated power law distributions of persistence times and are consistent with the Lévy walks that are also often employed by animal predators searching for scarce prey or food sources. In contrast, non-metastatic cancerous cells perform simple diffusive movements. These findings are supported by preliminary experiments with cancer cells migrating away from primary tumors in vivo. The use of chemical inhibitors targeting actin-binding proteins allows for “reprogramming” the Lévy walks into either diffusive or ballistic movements. © The Author(s) 2018
URI
https://pr.ibs.re.kr/handle/8788114/5162
ISSN
2041-1723
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > Journal Papers (저널논문)
Files in This Item:
2018_Bartosz_Nature Comm..pdfDownload

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