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Anisha Shakya
첨단연성물질 연구단
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Non-Fickian Molecular Transport in Protein–DNA Droplets

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Title
Non-Fickian Molecular Transport in Protein–DNA Droplets
Author(s)
Anisha Shakya; John T King
Publication Date
2018-10
Journal
ACS Macro Letters, v.7, no.10, pp.1220 - 1225
Publisher
AMER CHEMICAL SOC
Abstract
Bulk-level measurements of dynamics have suggested that phase-separated, protein–nucleic acid rich droplets can be viewed as simple liquids. In this report, we show that histone proteins spontaneously phase separate into liquid-like droplets in the presence of DNA. Using super-resolution fluorescence microscopy, we find that molecular transport in these droplets is non-Fickian (subdiffusive) at nanoscopic length scales. This observation cannot be explained by charge–charge interactions. Instead, our results strongly suggest that cation−π interactions drive the non-Fickian behavior. Given the ubiquity of cationic and aromatic moieties in protein–nucleic acid rich liquid-like phases observed in cells, we anticipate that non-Fickian diffusion is a general transport mechanism in such phases. © 2018 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/5147
ISSN
2161-1653
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > Journal Papers (저널논문)
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