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Non-Fickian Molecular Transport in Protein–DNA Droplets

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dc.contributor.authorAnisha Shakya-
dc.contributor.authorJohn T King-
dc.date.available2019-01-03T05:32:02Z-
dc.date.created2018-10-25-
dc.date.issued2018-10-
dc.identifier.issn2161-1653-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/5147-
dc.description.abstractBulk-level measurements of dynamics have suggested that phase-separated, protein–nucleic acid rich droplets can be viewed as simple liquids. In this report, we show that histone proteins spontaneously phase separate into liquid-like droplets in the presence of DNA. Using super-resolution fluorescence microscopy, we find that molecular transport in these droplets is non-Fickian (subdiffusive) at nanoscopic length scales. This observation cannot be explained by charge–charge interactions. Instead, our results strongly suggest that cation−π interactions drive the non-Fickian behavior. Given the ubiquity of cationic and aromatic moieties in protein–nucleic acid rich liquid-like phases observed in cells, we anticipate that non-Fickian diffusion is a general transport mechanism in such phases. © 2018 American Chemical Society-
dc.description.uri1-
dc.language영어-
dc.publisherAMER CHEMICAL SOC-
dc.titleNon-Fickian Molecular Transport in Protein–DNA Droplets-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000447816300014-
dc.identifier.scopusid2-s2.0-85053704114-
dc.identifier.rimsid65875-
dc.contributor.affiliatedAuthorAnisha Shakya-
dc.contributor.affiliatedAuthorJohn T King-
dc.identifier.doi10.1021/acsmacrolett.8b00565-
dc.identifier.bibliographicCitationACS MACRO LETTERS, v.7, no.10, pp.1220 - 1225-
dc.citation.titleACS MACRO LETTERS-
dc.citation.volume7-
dc.citation.number10-
dc.citation.startPage1220-
dc.citation.endPage1225-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusPHASE-SEPARATION-
dc.subject.keywordPlusDYNAMICS-
dc.subject.keywordPlusORGANELLES-
dc.subject.keywordPlusHETEROCHROMATIN-
dc.subject.keywordPlusORGANIZATION-
dc.subject.keywordPlusTRANSITIONS-
dc.subject.keywordPlusMECHANISMS-
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > 1. Journal Papers (저널논문)
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