Self-assembled adhesive biomaterials formed by a genetically designed fusion protein

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Title
Self-assembled adhesive biomaterials formed by a genetically designed fusion protein
Author(s)
Pulakesh Aich; Jaeyeon An; Byeongseon Yang; Young Ho Ko; Junghyun Kim; James Murray; Hyung Joon Cha; Joon Ho Roh; Kyeng Min Park; Kimoon Kim
Publication Date
2018-11
Journal
CHEMICAL COMMUNICATIONS, v.54, no.89, pp.12642 - 12645
Publisher
ROYAL SOC CHEMISTRY
Abstract
Here we report a recombinant protein (MS) obtained by genetic fusion of a mussel foot protein (Mfp3) motif into a silk spidroin (MaSp1). The MS not only self-assembled into a supramolecular fibre, as does the parent MaSp1, but also showed enhanced adhesiveness resulting from the DOPA-containing Mfp3 portion. The successful incorporation of the wet adhesiveness of Mfp3 into the well-structured assembly of MaSp1 may provide a new insight for the genetic design of underwater adhesive recombinant proteins by utilizing the structural features of a spidroin protein. © The Royal Society of Chemistry
URI
https://pr.ibs.re.kr/handle/8788114/5080
ISSN
1359-7345
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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