BROWSE

Related Scientist

Researcher

나노입자 연구단
나노입자 연구단
more info

pH-Sensitive Pt Nanocluster Assembly Overcomes Cisplatin Resistance and Heterogeneous Stemness of Hepatocellular Carcinoma

Cited 0 time in webofscience Cited 0 time in scopus
24 Viewed 1 Downloaded
Title
pH-Sensitive Pt Nanocluster Assembly Overcomes Cisplatin Resistance and Heterogeneous Stemness of Hepatocellular Carcinoma
Author(s)
Xia, HP; Li, FY; Park, W; Wang, SF; Youngjin Jang; Du, Y; Seungmin Baik; Cho, S; Taegyu Kang; Kim, DH; Ling, DS; Hui, KM; Taeghwan Hyeon
Publication Date
2016-11
Journal
ACS CENTRAL SCIENCE, v.2, no.11, pp.802 - 811
Publisher
AMER CHEMICAL SOC
Abstract
Response rates to conventional chemotherapeutics remain unsatisfactory for hepatocellular carcinoma (HCC) due to the high rates of chemoresistance and recurrence. Tumor-initiating cancer stem-like cells (CSLCs) are refractory to chemotherapy, and their enrichment leads to subsequent development of chemoresistance and recurrence. To overcome the chemoresistance and stemness in HCC, we synthesized a Pt nanocluster assembly (Pt-NA) composed of assembled Pt nanoclusters incorporating a pH-sensitive polymer and HCC-targeting peptide. Pt-NA is latent in peripheral blood, readily targets disseminated HCC CSLCs, and disassembles into small Pt nanoclusters in acidic subcellular compartments, eventually inducing damage to DNA. Furthermore, treatment with Pt-NA downregulates a multitude of genes that are vital for the proliferation of HCC. Importantly, CD24+ side population (SP) CSLCs that are resistant to cisplatin are sensitive to Pt-NA, demonstrating the immense potential of Pt-NA for treating chemoresistant HCC © 2016 American Chemical Society
URI
http://pr.ibs.re.kr/handle/8788114/5014
ISSN
2374-7943
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
Files in This Item:
pH-Sensitive Pt Nanocluster Assembly.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse