General and Facile Coating of Single Cells via Mild Reduction

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Title
General and Facile Coating of Single Cells via Mild Reduction
Author(s)
Hyunbum Kim; Kwangsoo Shin; Ok Kyu Park; Daheui Choi; Hwan D. Kim; Seungmin Baik; Soo Hong Lee; Kwon S.-H.; Yarema K.J.; Hong J.; Taeghwan Hyeon; Nathaniel S. Hwang
Publication Date
2018-01
Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.140, no.4, pp.1199 - 1202
Publisher
AMER CHEMICAL SOC
Abstract
Cell surface modification has been extensively studied to enhance the efficacy of cell therapy. Still, general accessibility and versatility are remaining challenges to meet the increasing demand for cell-based therapy. Herein, we present a facile and universal cell surface modification method that involves mild reduction of disulfide bonds in cell membrane protein to thiol groups. The reduced cells are successfully coated with biomolecules, polymers, and nanoparticles for an assortment of applications, including rapid cell assembly, in vivo cell monitoring, and localized cell-based drug delivery. No adverse effect on cellular morphology, viability, proliferation, and metabolism is observed. Furthermore, simultaneous coating with polyethylene glycol and dexamethasone-loaded nanoparticles facilitates enhanced cellular activities in mice, overcoming immune rejection. © 2017 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/4700
ISSN
0002-7863
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
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