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첨단연성물질 연구단
첨단연성물질 연구단
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Liquid biopsy in lung cancer: Clinical applications of circulating biomarkers (CTCs and ctDNA)

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Title
Liquid biopsy in lung cancer: Clinical applications of circulating biomarkers (CTCs and ctDNA)
Author(s)
Minji Lim; Chi-Ju Kim; Vijaya Sunkara; Mi-Hyun Kim; Yoon-Kyoung Cho
Publication Date
2018-02
Journal
MICROMACHINES, v.9, no.3, pp.100 -
Publisher
MDPI AG
Abstract
Lung cancer is by far the leading cause of cancer death worldwide, with non-small cell lung cancer (NSCLC) accounting for the majority of cases. Recent advances in the understanding of the biology of tumors and in highly sensitive detection technologies for molecular analysis offer targeted therapies, such as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. However, our understanding of an individual patient's lung cancer is often limited by tumor accessibility because of the high risk and invasive nature of current tissue biopsy procedures. Liquid biopsy, the analysis of circulating biomarkers from peripheral blood, such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA), offers a new source of cancer-derived materials that may reflect the status of the disease better and thereby contribute to more personalized treatment. In this review, we examined the clinical significance and uniqueness of CTCs and ctDNA from NSCLC patients, isolation and detection methods developed to analyze each type of circulating biomarker, and examples of clinical studies of potential applications for early diagnosis, prognosis, treatment monitoring, and prediction of resistance to therapy. We also discuss challenges that remain to be addressed before such tools are implemented for routine use in clinical settings. © 2018 by the authors
URI
https://pr.ibs.re.kr/handle/8788114/4682
ISSN
2072-666X
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > Journal Papers (저널논문)
Files in This Item:
2018_Yoon_MicroMachines_Liquid biopsy in lung cancer Clinical applications of circulating biomarkers (CTCs and ctDNA)_해당.pdfDownload

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