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Inflachromene inhibits autophagy through modulation of Beclin 1 activity

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Title
Inflachromene inhibits autophagy through modulation of Beclin 1 activity
Author(s)
Young Hun Kim; Man Sup Kwak; Jae Min Shin; Ria Aryani Hayuningtyas; Ji Eun Choi; Jeon-Soo Shin
Publication Date
2018-02
Journal
JOURNAL OF CELL SCIENCE, v.131, no.4, pp. -
Publisher
COMPANY OF BIOLOGISTS LTD
Abstract
Autophagy is a central intracellular catabolic mechanism that mediates the degradation of cytoplasmic proteins and organelles, and regulation of autophagy is essential for homeostasis. HMGB1 is an important sepsis mediator when secreted and also functions as an inducer of autophagy by binding to Beclin 1. In this study, we studied the effect of inflachromene (ICM), a novel HMGB1 secretion inhibitor, on autophagy. ICM inhibited autophagy by inhibiting nucleocytoplasmic translocation of HMGB1 and by increasing Beclin 1 ubiquitylation for degradation by enhancing the interaction between Beclin 1 and E3 ubiquitin ligase RNF216. These data suggest that ICM could be used as a potential autophagy suppressor. © 2018. Published by The Company of Biologists Ltd
URI
http://pr.ibs.re.kr/handle/8788114/4661
ISSN
0021-9533
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > Journal Papers
Files in This Item:
26.Journal of Cell Science 131, jcs211201, (2018).pdfDownload

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