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Inflachromene inhibits autophagy through modulation of Beclin 1 activity

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dc.contributor.authorYoung Hun Kim-
dc.contributor.authorMan Sup Kwak-
dc.contributor.authorJae Min Shin-
dc.contributor.authorRia Aryani Hayuningtyas-
dc.contributor.authorJi Eun Choi-
dc.contributor.authorJeon-Soo Shin-
dc.date.available2018-07-18T02:05:41Z-
dc.date.created2018-04-16-
dc.date.issued2018-02-
dc.identifier.issn0021-9533-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/4661-
dc.description.abstractAutophagy is a central intracellular catabolic mechanism that mediates the degradation of cytoplasmic proteins and organelles, and regulation of autophagy is essential for homeostasis. HMGB1 is an important sepsis mediator when secreted and also functions as an inducer of autophagy by binding to Beclin 1. In this study, we studied the effect of inflachromene (ICM), a novel HMGB1 secretion inhibitor, on autophagy. ICM inhibited autophagy by inhibiting nucleocytoplasmic translocation of HMGB1 and by increasing Beclin 1 ubiquitylation for degradation by enhancing the interaction between Beclin 1 and E3 ubiquitin ligase RNF216. These data suggest that ICM could be used as a potential autophagy suppressor. © 2018. Published by The Company of Biologists Ltd-
dc.description.uri1-
dc.language영어-
dc.publisherCOMPANY OF BIOLOGISTS LTD-
dc.subjectAutophagy-
dc.subjectBeclin 1-
dc.subjectInflachromene-
dc.subjectRNF216-
dc.titleInflachromene inhibits autophagy through modulation of Beclin 1 activity-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000426356000015-
dc.identifier.scopusid2-s2.0-85042418958-
dc.identifier.rimsid63092ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorJeon-Soo Shin-
dc.identifier.doi10.1242/jcs.211201-
dc.identifier.bibliographicCitationJOURNAL OF CELL SCIENCE, v.131, no.4-
dc.citation.titleJOURNAL OF CELL SCIENCE-
dc.citation.volume131-
dc.citation.number4-
dc.date.scptcdate2018-10-01-
dc.description.scptc0-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordAuthorAutophagy-
dc.subject.keywordAuthorBeclin 1-
dc.subject.keywordAuthorInflachromene-
dc.subject.keywordAuthorRNF216-
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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26.Journal of Cell Science 131, jcs211201, (2018).pdfDownload

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