T1 shortening in the globus pallidus after multiple administrations of gadobutrol: Assessment with a multidynamic multiecho sequence

Cited 0 time in webofscience Cited 0 time in scopus
103 Viewed 57 Downloaded
Title
T1 shortening in the globus pallidus after multiple administrations of gadobutrol: Assessment with a multidynamic multiecho sequence
Author(s)
Koung Mi Kang; Seung Hong Choi; Moonjung Hwang; Tae JIn Yun; Ji-hoon Kim; Chul-Ho Sohn
Publication Date
2018-04
Journal
RADIOLOGY, v.287, no.1, pp.258 - 266
Publisher
RADIOLOGICAL SOC NORTH AMERICA
Abstract
Purpose: To determine the association between the administration of the macrocyclic contrast medium gadobutrol and T1 relaxation time in the brains of patients with normal renal function by using multidynamic multiecho (MDME) magnetic resonance (MR) imaging sequences. Materials and Methods: The institutional review board approved this retrospective study, and the need to obtain written informed consent was waived. This study included 46 patients (revealed by an electronic medical record search) who had received one or more gadobutrol injections and a maximum of one MR imaging contrast medium injection other than gadobutrol before MDME sequence acquisition. One radiologist performed quantitative analyses of regions of interest on quantitative T1 maps twice to cover the normal-Appearing globus pallidus (GP), frontal white matter, frontal cortex, and thalamus. The number of administrations and the cumulative dose of gadobutrol, age, intervals between administrations, sex, and treatment were investigated. Univariable and multivariable linear regression analyses of the T1 values in four brain regions and the GP-To-Thalamus signal intensity (SI) ratio were performed. P values of less than the Bonferroni-corrected value of .01 were considered to indicate significant differences. Results: Intraobserver reproducibility was good to excellent (intraclass correlation coefficients, 0.62-0.81). Because of high multicollinearity between the number of gadobutrol administrations and accumulated dose (r = 0.96, P < .001), the number of gadobutrol administrations was considered in the regression analyses. T1 shortening in the GP was independently associated with the number of gadobutrol administrations (P = .002). T1 in the other brain regions and the GP-To-Thalamus SI ratio were not significantly associated with the number of gadobutrol administrations (P > .01). Conclusion: Multiple exposures to gadobutrol are associated with T1 shortening in the GP. © 2017 RSNA
URI
https://pr.ibs.re.kr/handle/8788114/4583
ISSN
0033-8419
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
Files in This Item:
radiol.2017162852.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse