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Dynamic Nanoparticle Assemblies for Biomedical Applications

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Title
Dynamic Nanoparticle Assemblies for Biomedical Applications
Author(s)
Fangyuan Li; Jingxiong Lu; Xueqian Kong; Taeghwan Hyeon; Daishun Ling
Publication Date
2017-04
Journal
ADVANCED MATERIALS, v.29, no.14, pp.1605897 -
Publisher
WILEY-V C H VERLAG GMBH
Abstract
Designed synthesis and assembly of nanoparticles assisted by their surface ligands can create “smart” materials with programmed responses to external stimuli for biomedical applications. These assemblies can be designed to respond either exogenously (for example, to magnetic field, temperature, ultrasound, light, or electric pulses) or endogenously (to pH, enzymatic activity, or redox gradients) and play an increasingly important role in a diverse range of biomedical applications, such as biosensors, drug delivery, molecular imaging, and novel theranostic systems. In this review, the recent advances and challenges in the development of stimuli-responsive nanoparticle assemblies are summarized; in particular, the application-driven design of surface ligands for stimuli-responsive nanoparticle assemblies that are capable of sensing small changes in the disease microenvironment, which induce the related changes in their physico-chemical properties, is described. Finally, possible future research directions and problems that have to be addressed are briefly discussed. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
URI
https://pr.ibs.re.kr/handle/8788114/4338
ISSN
0935-9648
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
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