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면역미생물공생연구단
면역 미생물 공생 연구단
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Interleukin-7 Availability Is Maintained by a Hematopoietic Cytokine Sink Comprising Innate Lymphoid Cells and T Cells

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Title
Interleukin-7 Availability Is Maintained by a Hematopoietic Cytokine Sink Comprising Innate Lymphoid Cells and T Cells
Author(s)
Christopher E. Martin; Darina S. Spasova; Kwesi Frimpong-Boateng; Hee-Ok Kim; Minji Lee; Kwang Soon Kim; Charles D. Surh
Publication Date
2017-07
Journal
IMMUNITY, v.47, no.1, pp.171 - 182
Publisher
CELL PRESS
Abstract
Interleukin-7 (IL-7) availability determines the size and proliferative state of the resting T cell pool. However, the mechanisms that regulate steady-state IL-7 amounts are unclear. Using experimental lymphopenic mouse models and IL-7-induced homeostatic proliferation to measure IL-7 availability in vivo, we found that radioresistant cells were the source of IL-7 for both CD4+ and CD8+ T cells. Hematopoietic lineage cells, although irrelevant as a source of IL-7, were primarily responsible for limiting IL-7 availability via their expression of IL-7R. Unexpectedly, innate lymphoid cells were found to have a potent influence on IL-7 amounts in the primary and secondary lymphoid tissues. These results demonstrate that IL-7 homeostasis is achieved through consumption by multiple subsets of innate and adaptive immune cells. (c) 2017 Elsevier Inc.
URI
https://pr.ibs.re.kr/handle/8788114/4210
ISSN
1074-7613
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
Files in This Item:
(2017)Interleukin-7 Availability Is Maintained by a Hematopoietic Cytokine Sink Comprising Innate Lymphoid Cells and T Cells.pdfDownload

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