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나노입자 연구단
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Continuous O-2-Evolving MnFe2O4 Nanoparticle-Anchored Mesoporous Silica Nanoparticles for Efficient Photodynamic Therapy in Hypoxic Cancer Highly Cited Paper

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Title
Continuous O-2-Evolving MnFe2O4 Nanoparticle-Anchored Mesoporous Silica Nanoparticles for Efficient Photodynamic Therapy in Hypoxic Cancer
Author(s)
Jonghoon Kim; Hye Rim Cho; Hyejin Jeon; Dokyoon Kim; Changyeong Song; Nohyun Lee; Seung Hong Choi; Taeghwan Hyeon
Publication Date
2017-08
Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.139, no.32, pp.10992 - 10995
Publisher
AMER CHEMICAL SOC
Abstract
Therapeutic effects of photodynamic therapy (PDT) are limited by cancer hypoxia because the PDT process is dependent on O-2 concentration. Herein, we design biocompatible manganese ferrite nanoparticle-anchored mesoporous silica nanoparticles (MFMSNs) to overcome hypoxia, consequently enhancing the therapeutic efficiency of PDT. By exploiting the continuous O-2-evolving property of MnFe2O4 nanoparticles through the Fenton reaction, MFMSNs relieve hypoxic condition using a small amount of nanoparticles and improve therapeutic outcomes of PDT for tumors in vivo. In addition, MFMSNs exhibit T-2 contrast effect in magnetic resonance imaging (MRI), allowing in vivo tracking of MFMSNs. These findings demonstrate great potential of MFMSNs for theranostic agents in cancer therapy. © 2017 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/4203
ISSN
0002-7863
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
Files in This Item:
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