BROWSE

Related Scientist

Researcher

유전체 항상성 연구단
유전체 항상성 연구단
more info

TET family dioxygenases and DNA demethylation in stem cells and cancers

Cited 10 time in webofscience Cited 0 time in scopus
177 Viewed 45 Downloaded
Title
TET family dioxygenases and DNA demethylation in stem cells and cancers
Author(s)
Jungeun An; Anjana Rao; Myunggon Ko
Publication Date
2017-04
Journal
EXPERIMENTAL AND MOLECULAR MEDICINE, v.49, no.4, pp.e323 -
Publisher
KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY
Abstract
The methylation of cytosine and subsequent oxidation constitutes a fundamental epigenetic modification in mammalian genomes, and its abnormalities are intimately coupled to various pathogenic processes including cancer development. Enzymes of the Ten-eleven translocation (TET) family catalyze the stepwise oxidation of 5-methylcytosine in DNA to 5-hydroxymethylcytosine and further oxidation products. These oxidized 5-methylcytosine derivatives represent intermediates in the reversal of cytosine methylation, and also serve as stable epigenetic modifications that exert distinctive regulatory roles. It is becoming increasingly obvious that TET proteins and their catalytic products are key regulators of embryonic development, stem cell functions and lineage specification. Over the past several years, the function of TET proteins as a barrier between normal and malignant states has been extensively investigated. Dysregulation of TET protein expression or function is commonly observed in a wide range of cancers. Notably, TET loss-of-function is causally related to the onset and progression of hematologic malignancy in vivo. In this review, we focus on recent advances in the mechanistic understanding of DNA methylation-demethylation dynamics, and their potential regulatory functions in cellular differentiation and oncogenic transformation. (c) 2017 KSBMB. All rights reserved
URI
http://pr.ibs.re.kr/handle/8788114/4152
DOI
10.1038/emm.2017.5
ISSN
1226-3613
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > Journal Papers (저널논문)
Files in This Item:
33_TET family dioxygenases and DNA demethylation in stem cells and cancers.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse