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유전체 항상성 연구단
유전체 항상성 연구단
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TET family dioxygenases and DNA demethylation in stem cells and cancers

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dc.contributor.authorJungeun Annull
dc.contributor.authorAnjana Raonull
dc.contributor.authorMyunggon Konull
dc.date.accessioned2018-01-04T06:45:02Z-
dc.date.available2018-01-04T06:45:02Z-
dc.date.created2017-07-19null
dc.date.issued201704null
dc.identifier.issn1226-3613null
dc.identifier.urihttp://pr.ibs.re.kr/handle/8788114/4152-
dc.description.abstractThe methylation of cytosine and subsequent oxidation constitutes a fundamental epigenetic modification in mammalian genomes, and its abnormalities are intimately coupled to various pathogenic processes including cancer development. Enzymes of the Ten-eleven translocation (TET) family catalyze the stepwise oxidation of 5-methylcytosine in DNA to 5-hydroxymethylcytosine and further oxidation products. These oxidized 5-methylcytosine derivatives represent intermediates in the reversal of cytosine methylation, and also serve as stable epigenetic modifications that exert distinctive regulatory roles. It is becoming increasingly obvious that TET proteins and their catalytic products are key regulators of embryonic development, stem cell functions and lineage specification. Over the past several years, the function of TET proteins as a barrier between normal and malignant states has been extensively investigated. Dysregulation of TET protein expression or function is commonly observed in a wide range of cancers. Notably, TET loss-of-function is causally related to the onset and progression of hematologic malignancy in vivo. In this review, we focus on recent advances in the mechanistic understanding of DNA methylation-demethylation dynamics, and their potential regulatory functions in cellular differentiation and oncogenic transformation. (c) 2017 KSBMB. All rights reservednull
dc.languageENGnull
dc.publisherKOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGYnull
dc.titleTET family dioxygenases and DNA demethylation in stem cells and cancersnull
dc.typeARTICLEnull
dc.type.rimsAnull
dc.identifier.wosid000404157000012null
dc.identifier.scopusid2-s2.0-85021329167null
dc.identifier.pid750null
dc.description.wostc10-
dc.date.scptcdate2018-10-01-
dc.identifier.doi10.1038/emm.2017.5null
dc.identifier.bibliographicCitationEXPERIMENTAL AND MOLECULAR MEDICINE, v.49, no.4, pp.e323 - null
dc.date.tcdate2018-10-01-
dc.description.scptc7-
dc.type.docTypeReview-
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Center for Genomic Integrity(유전체 항상성 연구단) > Journal Papers (저널논문)
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