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Impaired auditory evoked potentials and oscillations in frontal and auditory cortex of a schizophrenia mouse model.

Cited 11 time in webofscience Cited 11 time in scopus
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Title
Impaired auditory evoked potentials and oscillations in frontal and auditory cortex of a schizophrenia mouse model.
Author(s)
Yalda Shahriari; Dean Krusienski; Yamini Sureka Dadi; Misun Seo; Hee-Sup Shin; Jee Hyun Choi
Subject
Schizophrenia, ; mouse, ; auditory-steady-stateresponse, ; EEG, ; oscillations
Publication Date
2016-09
Journal
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, v.17, no.6, pp.439 - 448
Publisher
INFORMA HEALTHCARE
Abstract
Objectives: In patients with schizophrenia, g-band (30–70 Hz) auditory steady-state electroencephalogram responses (ASSR) are reduced in power and phase locking. Here, we examined whether g-ASSR deficits are also present in a mouse model of schizophrenia, whose behavioural changes have shown schizophrenia-like endophenotypes. Methods: Electroencephalogram in frontal cortex and local field potential in primary auditory cortex were recorded in phospholipase C b1 (PLC-b1) null mice during auditory binaural click trains at different rates (20–50 Hz), and compared with wildtype littermates. Results: In mutant mice, the ASSR power was reduced at all tested rates. The phase locking in frontal cortex was reduced in the b band (20 Hz) but not in the g band, whereas the phase locking in auditory cortex was reduced in the g band. The cortico-cortical connectivity between frontal and auditory cortex was significantly reduced in mutant mice. Conclusions: The tested mouse model of schizophrenia showed impaired electrophysiological responses to auditory steady state stimulation, suggesting that it could be useful for preclinical studies of schizophrenia’’. (c) 2016 Taylor & Francis
URI
https://pr.ibs.re.kr/handle/8788114/3832
DOI
10.3109/15622975.2015.1112036
ISSN
1562-2975
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
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