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Impaired auditory evoked potentials and oscillations in frontal and auditory cortex of a schizophrenia mouse model.

DC Field Value Language
dc.contributor.authorYalda Shahriari-
dc.contributor.authorDean Krusienski-
dc.contributor.authorYamini Sureka Dadi-
dc.contributor.authorMisun Seo-
dc.contributor.authorHee-Sup Shin-
dc.contributor.authorJee Hyun Choi-
dc.date.available2017-10-10T01:49:11Z-
dc.date.created2017-03-30-
dc.date.issued2016-09-
dc.identifier.issn1562-2975-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/3832-
dc.description.abstractObjectives: In patients with schizophrenia, g-band (30–70 Hz) auditory steady-state electroencephalogram responses (ASSR) are reduced in power and phase locking. Here, we examined whether g-ASSR deficits are also present in a mouse model of schizophrenia, whose behavioural changes have shown schizophrenia-like endophenotypes. Methods: Electroencephalogram in frontal cortex and local field potential in primary auditory cortex were recorded in phospholipase C b1 (PLC-b1) null mice during auditory binaural click trains at different rates (20–50 Hz), and compared with wildtype littermates. Results: In mutant mice, the ASSR power was reduced at all tested rates. The phase locking in frontal cortex was reduced in the b band (20 Hz) but not in the g band, whereas the phase locking in auditory cortex was reduced in the g band. The cortico-cortical connectivity between frontal and auditory cortex was significantly reduced in mutant mice. Conclusions: The tested mouse model of schizophrenia showed impaired electrophysiological responses to auditory steady state stimulation, suggesting that it could be useful for preclinical studies of schizophrenia’’. (c) 2016 Taylor & Francis-
dc.description.uri1-
dc.language영어-
dc.publisherINFORMA HEALTHCARE-
dc.subjectSchizophrenia-
dc.subjectmouse-
dc.subjectauditory-steady-stateresponse-
dc.subjectEEG-
dc.subjectoscillations-
dc.titleImpaired auditory evoked potentials and oscillations in frontal and auditory cortex of a schizophrenia mouse model.-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000383408000004-
dc.identifier.scopusid2-s2.0-84955142417-
dc.identifier.rimsid59101-
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorHee-Sup Shin-
dc.identifier.doi10.3109/15622975.2015.1112036-
dc.identifier.bibliographicCitationWORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, v.17, no.6, pp.439 - 448-
dc.citation.titleWORLD JOURNAL OF BIOLOGICAL PSYCHIATRY-
dc.citation.volume17-
dc.citation.number6-
dc.citation.startPage439-
dc.citation.endPage448-
dc.date.scptcdate2018-10-01-
dc.description.wostc2-
dc.description.scptc3-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
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