Impaired auditory evoked potentials and oscillations in frontal and auditory cortex of a schizophrenia mouse model.

DC Field Value Language
dc.contributor.authorYalda Shahriari-
dc.contributor.authorDean Krusienski-
dc.contributor.authorYamini Sureka Dadi-
dc.contributor.authorMisun Seo-
dc.contributor.authorHee-Sup Shin-
dc.contributor.authorJee Hyun Choi-
dc.date.available2017-10-10T01:49:11Z-
dc.date.created2017-03-30-
dc.date.issued2016-09-
dc.identifier.issn1562-2975-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/3832-
dc.description.abstractObjectives: In patients with schizophrenia, g-band (30–70 Hz) auditory steady-state electroencephalogram responses (ASSR) are reduced in power and phase locking. Here, we examined whether g-ASSR deficits are also present in a mouse model of schizophrenia, whose behavioural changes have shown schizophrenia-like endophenotypes. Methods: Electroencephalogram in frontal cortex and local field potential in primary auditory cortex were recorded in phospholipase C b1 (PLC-b1) null mice during auditory binaural click trains at different rates (20–50 Hz), and compared with wildtype littermates. Results: In mutant mice, the ASSR power was reduced at all tested rates. The phase locking in frontal cortex was reduced in the b band (20 Hz) but not in the g band, whereas the phase locking in auditory cortex was reduced in the g band. The cortico-cortical connectivity between frontal and auditory cortex was significantly reduced in mutant mice. Conclusions: The tested mouse model of schizophrenia showed impaired electrophysiological responses to auditory steady state stimulation, suggesting that it could be useful for preclinical studies of schizophrenia’’. (c) 2016 Taylor & Francis-
dc.languageENG-
dc.publisherINFORMA HEALTHCARE-
dc.titleImpaired auditory evoked potentials and oscillations in frontal and auditory cortex of a schizophrenia mouse model.-
dc.typeArticle-
dc.type.rimsA-
dc.identifier.wosid000383408000004-
dc.identifier.scopusid2-s2.0-84955142417-
dc.description.wostc2-
dc.date.tcdate2018-10-01-
dc.date.scptcdate2018-10-01-
dc.subject.keywordSchizophrenia-
dc.subject.keywordmouse-
dc.subject.keywordauditory-steady-stateresponse-
dc.subject.keywordEEG-
dc.subject.keywordoscillations-
dc.contributor.affiliatedAuthorHee-Sup Shin-
dc.identifier.bibliographicCitationWORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, v.17, no.6, pp.439 - 448-
dc.description.scptc3-
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Journal Papers (저널논문)
Files in This Item:
170. Impaired auditory evoked potentials and oscillations in frontal and auditory cortex of a schizophrenia mouse model..pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse