Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal in vivo imaging

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Title
Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal in vivo imaging
Author(s)
Sungwan Kim; Gyeongwon Yun; Suman Khan; Jinhwan Kim; James Murray; Yeong Mi Lee; Won Jong Kim; Gyudong Lee; Sungjee Kim; Dinesh Shetty; Joo Hyun Kang; Jung Young Kim; Kyeng Min Park; Kimoon Kim
Publication Date
2017-03
Journal
MATERIALS HORIZONS, v.4, no.3, pp.450 - 455
Publisher
ROYAL SOC CHEMISTRY
Abstract
Cucurbit[6]uril (CB[6])-based polymer nanocapsules (CB[6]PNs) were used as a multimodal platform for cancer-targeted in vivo bioimaging. By taking advantage of the strong and robust host-guest interaction between CB[6] and spermidine (spmd) under in vivo conditions, the surface of the CB[6]PNs was non-covalently modified with various spmd-conjugated functionalities in a modular manner. The CB[6]PNs modified with imaging probes and targeting ligands showed tumor targeted PET and NIR imaging in mice. This proof of concept demonstrates the potential of non-covalently modified nanomaterials in real world in vivo systems. This journal is © The Royal Society of Chemistry 2017
URI
https://pr.ibs.re.kr/handle/8788114/3762
ISSN
2051-6347
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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