IBS Publications Repository: Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal in vivo imaging

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Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal in vivo imaging

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Title: Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal in vivo imaging

Author(s): Sungwan Kim; Gyeongwon Yun; Suman Khan; Jinhwan Kim; James Murray; Yeong Mi Lee; Won Jong Kim; Gyudong Lee; Sungjee Kim; Dinesh Shetty; Joo Hyun Kang; Jung Young Kim; Kyeng Min Park; Kimoon Kim

Subject: TARGETED DRUG-DELIVERY, ; NANOSTRUCTURED MATERIALS, ; GUIDED SURGERY, ; NANOPARTICLES, ; THERAPY, ; CANCER, ; SYSTEMS, ; PET, ; CHEMISTRY, ; VEHICLE

Abstract: Cucurbit[6]uril (CB[6])-based polymer nanocapsules (CB[6]PNs) were used as a multimodal platform for cancer-targeted in vivo bioimaging. By taking advantage of the strong and robust host-guest interaction between CB[6] and spermidine (spmd) under in vivo conditions, the surface of the CB[6]PNs was non-covalently modified with various spmd-conjugated functionalities in a modular manner. The CB[6]PNs modified with imaging probes and targeting ligands showed tumor targeted PET and NIR imaging in mice. This proof of concept demonstrates the potential of non-covalently modified nanomaterials in real world in vivo systems. This journal is © The Royal Society of Chemistry 2017