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Giant capsids from lattice self-assembly of cyclodextrin complexes

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Title
Giant capsids from lattice self-assembly of cyclodextrin complexes
Author(s)
Shenyu Yang; Yun Yan; Jianbin Huang; Andrei V. Petukhov; Loes M.J. Kroon-Batenburg; Markus Drechsler; Chengcheng Zhou; Mei Tu; Steve Granick; Lingxiang Jiang
Publication Date
2017-06
Journal
NATURE COMMUNICATIONS, v.8, no., pp.15856 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Proteins can readily assemble into rigid, crystalline and functional structures such as viral capsids and bacterial compartments. Despite ongoing advances, it is still a fundamental challenge to design and synthesize protein-mimetic molecules to form crystalline structures. Here we report the lattice self-assembly of cyclodextrin complexes into a variety of capsidlike structures such as lamellae, helical tubes and hollow rhombic dodecahedra. The dodecahedral morphology has not hitherto been observed in self-assembly systems. The tubes can spontaneously encapsulate colloidal particles and liposomes. The dodecahedra and tubes are respectively comparable to and much larger than the largest known virus. In particular, the resemblance to protein assemblies is not limited to morphology but extends to structural rigidity and crystallinity-a well-defined, 2D rhombic lattice of molecular arrangement is strikingly universal for all the observed structures. We propose a simple design rule for the current lattice self-assembly, potentially opening doors for new protein-mimetic materials. r The Author(s) 2017
URI
http://pr.ibs.re.kr/handle/8788114/3663
DOI
10.1038/ncomms15856
ISSN
2041-1723
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > Journal Papers (저널논문)
Files in This Item:
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