Prognosis prediction of non-enhancing T2 high signal intensity lesions in glioblastoma patients after standard treatment: application of dynamic contrast-enhanced MR imaging
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- Prognosis prediction of non-enhancing T2 high signal intensity lesions in glioblastoma patients after standard treatment: application of dynamic contrast-enhanced MR imaging
- Rihyeon Kim; Seung Hong Choi; Tae Jin Yun; Soon-Tae Lee; Chul-Kee Park; Tae Min Kim; Ji-Hoon Kim; Sun-Won Park; Chul-Ho Sohn; Sung-Hye Park; Il Han Kim
- EUROPEAN RADIOLOGY, v.27, no.3, pp.1176 - 1185
- Objectives To identify candidate imaging biomarkers for early
disease progression in glioblastoma multiforme (GBM) patients
by analysis of dynamic contrast-enhanced (DCE) MR
parameters of non-enhancing T2 high signal intensity (SI)
Methods Forty-nine GBM patients who had undergone preoperative
DCE MR imaging and received standard treatment
were retrospectively included. According to the Response
Assessment in Neuro-Oncology criteria, patients were classified
into progression (n = 21) or non-progression (n = 28)
groups. We analysed the pharmacokinetic parameters of
Ktrans, Ve and Vp within non-enhancing T2 high SI lesions
of each tumour. The best percentiles of each parameter from
cumulative histograms were identified by the area under the
receiver operating characteristic curve (AUC) and were compared
using multivariate stepwise logistic regression.
Results For the differentiation of early disease progression,
the highest AUC values were found in the 99th percentile of
Ktrans (AUC 0.954), the 97th percentile of Ve (AUC 0.815)
and the 94th percentile of Vp (AUC 0.786) (all p < 0.05). The
99th percentile of Ktrans was the only significant independent
variable from the multivariate stepwise logistic regression
(p = 0.002).
Conclusions We found that the Ktrans of non-enhancing T2
high SI lesions in GBMpatients holds potential as a candidate
prognostic marker in future prospective studies.
• DCE MR imaging provides candidate prognostic marker of
GBM after standard treatment.
• Cumulative histogram was applied to include entire nonenhancing
T2 high SI lesions.
• The 99th percentile value of Ktrans was the most likely
potential biomarker. (c) European Society of Radiology 2016
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