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A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy Highly Cited Paper

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Title
A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy
Author(s)
Hyunjae Lee; Tae Kyu Choi; Young Bum Lee; Hye Rim Cho; Roozbeh Ghaffari; Liu Wang; Hyung Jin Choi; Taek Dong Chung; Nanshu Lu; Taeghwan Hyeon; Seung Hong Choi; Dae-Hyeong Kim
Publication Date
2016-06
Journal
NATURE NANOTECHNOLOGY, v.11, no.6, pp.566 - 572
Publisher
NATURE PUBLISHING GROUP
Abstract
Owing to its high carrier mobility, conductivity, flexibility and optical transparency, graphene is a versatile material in micro- and macroelectronics. However, the low density of electrochemically active defects in graphene synthesized by chemical vapour deposition limits its application in biosensing. Here, we show that graphene doped with gold and combined with a gold mesh has improved electrochemical activity over bare graphene, sufficient to form a wearable patch for sweat-based diabetes monitoring and feedback therapy. The stretchable device features a serpentine bilayer of gold mesh and gold-doped graphene that forms an efficient electrochemical interface for the stable transfer of electrical signals. The patch consists of a heater, temperature, humidity, glucose and pH sensors and polymeric microneedles that can be thermally activated to deliver drugs transcutaneously. We show that the patch can be thermally actuated to deliver Metformin and reduce blood glucose levels in diabetic mice. © 2016 Macmillan Publishers Limited.
URI
https://pr.ibs.re.kr/handle/8788114/3298
ISSN
1748-3387
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
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