The Ca2+ -activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons

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Title
The Ca2+ -activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons
Author(s)
Go Eun Ha; Jaekwang Lee; Hankyul Kwak; Kiyeong Song; Jea Kwon; Soon-Young Jung; Joohyeon Hong; Gyeong-Eon Chang; Eun Mi Hwang; Hee-Sup Shin; C. Justin Lee; Eunji Cheong
Publication Date
2016-12
Journal
NATURE COMMUNICATIONS, v.7, no., pp.13791 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Neuronal firing patterns, which are crucial for determining the nature of encoded information, have been widely studied; however, the molecular identity and cellular mechanisms of spike-frequency adaptation are still not fully understood. Here we show that spike-frequency adaptation in thalamocortical (TC) neurons is mediated by the Ca2+ -activated Cl- channel (CACC) anoctamin-2 (ANO2). Knockdown of ANO2 in TC neurons results in significantly reduced spike-frequency adaptation along with increased tonic spiking. Moreover, thalamus-specific knockdown of ANO2 increases visceral pain responses. These results indicate that ANO2 contributes to reductions in spike generation in highly activated TC neurons and thereby restricts persistent information transmission. © The Author(s) 2016
URI
https://pr.ibs.re.kr/handle/8788114/3215
ISSN
2041-1723
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Journal Papers (저널논문)
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